Get ABC Proteins. From Bacteria to Man PDF

By I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003

ISBN-10: 0080481876

ISBN-13: 9780080481876

ABC Proteins is an in-depth, updated research of all that's identified in regards to the topic up to now. It discusses and compares evolution, biology and mechanism of motion of all identified ABC proteins, together with the 1st structural reports in addition to scientific implications. it will likely be priceless to somebody attempting to remain abreast of the newest findings. This booklet is bound to turn into a vintage and may frequently be updated.

Key Features

  • Phylogeny and Evoloution of ABC Transporters
  • Fundamental facets of the Mechanism of motion of ABC Transporters
  • Prokaryote ABC Transporters
  • Non-Mammalian Transporters
  • Multidrug Transporters
  • ABC Transporters, Physiological Roles and Human Disease
  • Full colour all through
  • Show description

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    Additional resources for ABC Proteins. From Bacteria to Man

    Sample text

    Biol. Chem. 1974;249:7747–7755. -L. Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport. Proc. Natl Acad. Sci. USA. 1989;86:6953–6957. J. Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein. EMBO J. 1999;23:6800–6808. B. Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters.

    Eukaryotic cells generally have fewer ABC transporters, presumably because other more sophisticated mechanisms for moving solutes across membranes have evolved. For example, cells which can absorb nutrients by endocytosis do not require ABC transporters for the uptake of nutrients, although ABC transporters still play an important role in the uptake of solutes into organelles (Almashanu and Valle, Chapter 24; Lill and Kispal, Chapter 25). Indeed, to date, there is no example of a eukaryotic ABC transporter with a role in uptake into the cytoplasm – all are exporters.

    Bohr-Gasse, 9/2, A-1030 Vienna, Austria Frances J. de, Institut für Biochemie, Biozentrum, Universität Frankfurt, Marie-Curie-Str. , Germany Gábor E. edu, Howard Hughes Medical Institute and The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 802 PCTB, 725 N. NL, Academic Medical Center, Laboratory of Cell Biology and Histology, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands Hendrik W. G. nl, The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands Anthony J.

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    ABC Proteins. From Bacteria to Man by I Barry Holland,Susan P. C. Cole,Karl Kuchler, et al.Elsevier|Elsevier Science||Academic PressAdult NonfictionScienceLanguage(s): EnglishOn sale date: 13.10.2011Street date: 07.01.2003

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