Saul L. Neidleman's Advances in Applied Microbiology, Vol. 44 PDF

By Saul L. Neidleman

ISBN-10: 0120026449

ISBN-13: 9780120026449

Compliment for the sequence "No laboratory scientist, box employee or technical administrator can manage to pay for to move it up." --ASM information "The issues are good supported through an intensive bibliography and supply a wealthy resource of present information." --Biopharm

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04 pg/ml. The helioferins I" BIOLOGICALLY ACTIVE FUNGAL METABOLITES O = ? ( :I2 33 34 CEDRIC PEARCE OH OH (105) (2-12371 R=H (106) CJ-12372 R=OH STRUCTURES 100-106. are linear aminolipopeptides and are thought to work as protonophoric compounds disrupting ion flux and energy metabolism. A number of compounds containing bicyclic decalin and related structures with a variety of bioactivity, but commonly antifungal, have been reported recently. Thus, the diepoxins 100-103 (Schlingmann et BIOLOGICALLY ACTIVE FUNGAL METABOLITES 35 (107) Australifungin OH (108) Australifunginol STRUCTURES 107, 108.

Two of these azaphilones (75 and 76) are novel sclerotiorin analogues and are similar to the isochromophilones, inhibitors of acyl-CoA:cholesterol acyltransferase, as discussed above. In binding studies with human ET, and ETb receptors using radiolabeled 24 CEDlUC PEARCE Azaphih (75)l R=CI (76)2 R=H (77) RES-12141 R*=OH, RFH, R,=OCH, (78) RES-1214-2 Rl=OH. R d I . R & C H 3 (79) Dihydroepiepofonin I OH STRUCTURES 75-79. endothelin-1, the IC,, values ranged between 56 and >250 pA4. In a third study, Ogawa and co-workers (1995) discovered two endothelin-1 antagonists from a Pestalotiopis sp.

1995) investigated a mutant of the patulin-producing Penicillium urticae, which was shown to produce a new azaphilone epoxide, patulodin (117a). This compound was shown to be weakly antifungal, having an MIC value of 50 p g h l against Pyricularia oryzae. As with the discovery of antiinsectan compounds (discussed in Section XI), Gloer and co-workers (1995a, 1996) have used an elegant discovery approach directed by nature and have sought antifungal compounds from fungi living in environments wherein the fungal inhabitants might be reasonably expected to compete for nutrients with each other.

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Advances in Applied Microbiology, Vol. 44 by Saul L. Neidleman


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