By K. Magyar
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Extra resources for Monoamine Oxidases and their Selective Inhibition. Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
Magyar, K. and Satory, E. (1978) Biochem. Pharmacol. 27^y 1739. , Sakalis, G. and Tansella, M. (1970) Psychopharmacologia, 1_8, 118. , Elsworth, J. , Sandler, M. H. (1977) The Lancet,791. , Ecsery, Z. and Knoll, J. (1967) Acta Physiol. Hung. 32,, 377. Magyar, K. , Satory, E. and Knoll, J. (1973) In Symposium on Pharmacological Agents and Biogenic Amines in the Nervous System. (Eds. Knoll, J. ) Akademiai Kiado, Budapest, pp. 107-122. Mendlewicz, J. H. (1978) J. Neural Transm. 43, 279. , Siirtola, T.
In a dose of 250 pg/r&t the compounds strongly diminished both the one hour and the one day consumption (Fig. 25 mg/kg J-508 * Significant Fig. 2. The effect of intravenously injected MAOIs on the food intake of rats deprived of food for 96 hours. N=25 iNTRACEREBROVENTRICULAR control 250 500 (-) Deprenyl ADMINISTRATION 250 Clorgyline 250 yug/ret J-508 » Significant Fig„ 3. The effect of intracerebroventricularly injected MAOIs on the food intake of rats deprived of food for 96 hours. N=25 Discussion According to our present knowledge there are species variations in the distribution of the two forms of M A O enzyme.
3, 4 and 5 are calculated ones, the experimental curves are very s i milar in the respect of resolution. Some experimental curves are slightly higher in consequence of non total proportionality of extinction with the concentration of these substances. 61 Fig. 4 The decreased number of components can be well separated on the original size of chromatographic column HALF SIZE OF COLUMN acetone tryptamine elution time 318 (minutes) 1 100-T% serotonin 75- A phenyl - 50- ethylamine A 25- \ l / dopamine A / / \ \ \ A A/ \ /b/ t*2U elution time (minutes) Fig.
Monoamine Oxidases and their Selective Inhibition. Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979 by K. Magyar